Type of Compound: Terpenoid

Medical Properties: 

AChE inhibitor

Antibiotic

Description:  Terpinen-4-ol is a monoterpene originally found in many plants and is one of the primary active ingredients in tea tree oil. Terpinen-4-ol exhibits anticancer chemotherapeutic, anti-inflammatory, antibacterial, and antifungal activities. In leukemia cells, terpinen-4-ol induces release of cytochrome c and activation of caspase 8, resulting in autophagy, apoptosis, and cell death. In non-small cell lung cancer (NSCLC) cells, terpinen-4-ol induces cleavage of poly(ADP)-ribose polymerase (PARP), activates caspases 3 and 9, decreases mitochondrial membrane potential, increases the Bax/Bcl-2 ratio, and increases levels of p53, resulting in apoptosis and cell death. Additionally, this compound decreases myeloperoxidase activity and expression of MIP-2 and other cytokines in animal models of oral candidiasis. Terpinen-4-ol displays antimicrobial activity against gram positive and gram negative bacteria such as Campylobacter as well as fungi such as Aspergillus and Fusarium. 

Boiling Point (F): 408 

Boiling Point (C):  209 

Melting Point (F): 

Melting Point (C): 

Concentration (% of dry weight): 0.0004% 

Relative Content (%):

Chemical Formula: C10H18O 

IUPAC Name: 4-methyl-1-propan-2-ylcyclohex-3-en-1-ol